valproic acid

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an antiepileptic drug

Välised allikad

MedlinePlus drug identifier	a682412
LEM ID	LEM201000081
MeSH descriptor ID	D014635 teema nimetus kujul: Valproic Acid
MeSH concept ID	M0022502
NSC number	93819
ChEMBL ID	CHEMBL109^[1]
Guide to Pharmacology Ligand ID	7009^[2]
MeSH tree code	D02.241.081.944.509.900 D10.251.400.895.593.900
AICS Chemical ID (BEING DELETED)	2297
ECHA Substance Infocard ID	100.002.525^[3]
PDB structure ID	1DIT^[4]
DrugCentral ID	2803^[5]
CAMEO Chemicals ID	21210
NALT ID	10274
Probes And Drugs ID	PD003158
LIPID MAPS ID	LMFA01020291
NDF-RT ID	N0000147028^[6] N0000020512^[7]
Freebase	/m/0fv82^[8]
CA PROP 65 ID	valproate^[9]
Reaxys registry number	1750447^[10]
LCCN	sh85141922^[11] teema nimetus kujul: Valproic acid
PubChem CID	3121^[12]^[13]
UniChem compound ID	271922^[5]
Quora topic ID	Valproic-Acid^[14]
YSO tunnus	22961^[15] teema nimetus kujul: valproaatti, valproat, valproic acid
PDB ligand ID	2PP
SPLASH	splash10-0002-9000000000-4ddd957d8c8dc2b1de03 splash10-0006-0900000000-6ba582ae102c4721034d splash10-0006-0900000000-58d9ba88010f1b370c58 splash10-0006-3900000000-2d1032d7e8ac58235b4f splash10-0a4j-9000000000-0d39870bc4521a42c50a splash10-00di-9000000000-3c4e21b69b8877d6df3e splash10-0006-0900000000-f0f6113a46ed434ca614 splash10-0f6y-2900000000-a769cafb885b78532cac splash10-0gbj-7900000000-46a522b9a26459334f5a splash10-0udi-2900000000-156413e81733a6236c1f splash10-0fk9-9300000000-1a0314ea63d5a3c9bba1
KEGG ID	C07185^[16]
OpenAlex ID	C2777172819^[17] C2908949014^[17]
UNII	614OI1Z5WI^[6]^[13]
InChIKey	NIJJYAXOARWZEE-UHFFFAOYSA-N^[12]^[18]
CAS Registry Number	99-66-1^[6]^[19]
DrugBank ID	DB00313^[13]
ChEBI ID	39867^[1]^[20] mapping relation type: täpne vaste
WikiProjectMed ID	Valproate
CosIng number	94126^[21]
ATC code	N03AG01^[22]
Human Metabolome Database ID	HMDB0001877^[23]^[13]
SureChEMBL ID	SCHEMBL2275^[23]^[13]
electronic Essential Medicines List medicine ID	55
DSSTox substance ID	DTXSID6023733^[24]^[13]
Microsoft Academic ID	2777172819 2777299702 2781267640 2909284039
EC number	202-777-3^[6]
DSSTOX compound identifier	DTXCID803733
NMRShiftDB structure ID	20200678^[13]
UMLS CUI	C0042291^[6]
InChI	InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)^[12]
ChemSpider ID	3009^[25]
BNCF Thesaurus ID	52464^[26]
BNF	122625973^[11] teema nimetus kujul: Valproïque, Acide
National Library of Israel J9U ID	987007531852805171^[27]
World Health Organisation international non-proprietary name numeric ID	3300^[28]
MassBank accession ID	MSBNK-Keio_Univ-KO001996 MSBNK-Keio_Univ-KO001997 MSBNK-Keio_Univ-KO001998 MSBNK-Keio_Univ-KO001999 MSBNK-Keio_Univ-KO002000 MSBNK-Keio_Univ-KO002001 MSBNK-Keio_Univ-KO002002
RxNorm ID	11118^[6]
HSDB ID	3582^[29]

üksikjuht nähtusest

type of chemical entity

mille alamklass

branched chain fatty acids

asutamise või loomise aeg

1967^[30]

keemiline struktuur

mass/kaal

144,115 aatommassiühik^[31]

oluline sündmus

Dépakine case

conjugate base

valproate

chemical formula

C₈H₁₆O₂^[12]

canonical SMILES

CCCC(CCC)C(=O)O^[12]

World Health Organisation international non-proprietary name

valproic acid^[16]^[32]

found in taxon

Harilik palderjan^[33]

medical condition treated

bipolaarne häire^[34]

early-onset Alzheimer's disease^[34]

childhood absence epilepsy^[34]

complex partial seizure^[34]

physically interacts with

histone deacetylase 1^[35]

subjektil on roll: Ensüümiinhibiitor

Aldehyde dehydrogenase 5 family member A1^[36]

subjektil on roll: Inhibiitor

legal status (medicine)

boxed warning^[37]

pregnancy category

Australian pregnancy category D

US pregnancy category X

subjektil on roll

Ensüümiinhibiitor^[38]

anticonvulsant agent^[38]

GABA agents^[38]

antimanic agents^[38]

essential medicine

developmental toxicant^[39]

algusaeg: 1. juuli 1987

mitte segamini ajada

valproate

sodium valproate

valproate calcium

Commonsi kategooria

Valproic acid

Viited

↑ ^1,0 ^1,1 ChEMBL, 19. november 2016, inglise keel, VALPROIC ACID, CHEMBL109
↑ IUPHAR/BPS Guide to PHARMACOLOGY, 19. november 2016, inglise keel, 7009, valproic acid
↑ ECHA Substance Infocard database, 27. detsember 2018, 100.002.525, 2-propylvaleric acid, CAS no.: 99-66-1
↑ Protein Data Bank, 19. oktoober 2016, inglise keel, 1DIT, 1DIT
↑ ^5,0 ^5,1 UniChem
↑ ^6,0 ^6,1 ^6,2 ^6,3 ^6,4 ^6,5 Global Substance Registration System, 19. november 2016, inglise keel, valproic acid, 614OI1Z5WI
↑ N0000020512, 26. veebruar 2018, NDF-RT
↑ Freebase Data Dumps, 28. oktoober 2013
↑ California Proposition 65 list of chemicals, 7. jaanuar 2020, https://oehha.ca.gov/chemicals/valproate
↑ ChEBI, 19. oktoober 2016, inglise keel, valproic acid, 39867
↑ ^11,0 ^11,1 Nuovo soggettario, https://thes.bncf.firenze.sbn.it/termine.php?id=52464, 17. juuni 2021
↑ ^12,0 ^12,1 ^12,2 ^12,3 ^12,4 PubChem, 19. november 2016, inglise keel, 3121, VALPROIC ACID
↑ ^13,0 ^13,1 ^13,2 ^13,3 ^13,4 ^13,5 ^13,6 NIJJYAXOARWZEE-UHFFFAOYSA-N, InChIKey
↑ Quora
↑ YSO-Wikidata mapping project, 9. veebruar 2022
↑ ^16,0 ^16,1 ChEMBL, 19. jaanuar 2016, inglise keel, Valproic Acid, CHEMBL109
↑ ^17,0 ^17,1 OpenAlex, 26. jaanuar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
↑ ChEBI release 2020-09-01
↑ CAS Common Chemistry, 9. aprill 2021, NIJJYAXOARWZEE-UHFFFAOYSA-N, https://commonchemistry.cas.org/detail?cas_rn=99-66-1
↑ International Chemical Identifier, InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
↑ CosIng database, 28. detsember 2019, 94126, VALPROIC ACID, CAS no.: 99-66-1
↑ DrugBank, inglise keel, 17. november 2015, 00313, Valproic Acid
↑ ^23,0 ^23,1 inferred from InChIKey
↑ Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
↑ ChemSpider, 19. november 2016, inglise keel, 3009, Valproic acid
↑ Firenze Keskrahvusraamatukogu
↑ National Library of Israel
↑ https://mednet-communities.net/inn/db/ViewINN.aspx?i=3300
↑ Hazardous Substances Data Bank, 10. mai 2021, 28. oktoober 2019, VALPROIC ACID, 3582
↑ https://www.aljazeera.com/economy/2020/8/3/frances-sanofi-charged-with-manslaughter-in-birth-defects-case
↑ PubChem, 19. oktoober 2016, inglise keel, 3121, VALPROIC ACID
↑ Recommended INN: List 13, 1973
↑ Alkaloid-Bearing Plants and Their Contained Alkaloids. 1957-1968
↑ ^34,0 ^34,1 ^34,2 ^34,3 N0000147028, 13. detsember 2016, NDF-RT, inglise keel
↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7009, inglise keel
↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL109
↑ FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links., https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802
↑ ^38,0 ^38,1 ^38,2 ^38,3 Medical Subject Headings, 15. märts 2018, D014635
↑ California Proposition 65 list of chemicals, 19. märts 2020, https://oehha.ca.gov/chemicals/valproate

[rce9c6b85-1] 1,0 ^1,1 ChEMBL, 19. november 2016, inglise keel, VALPROIC ACID, CHEMBL109

[ra9d22d34-2] IUPHAR/BPS Guide to PHARMACOLOGY, 19. november 2016, inglise keel, 7009, valproic acid

[r59d48534-3] ECHA Substance Infocard database, 27. detsember 2018, 100.002.525, 2-propylvaleric acid, CAS no.: 99-66-1

[r7cf08b94-4] Protein Data Bank, 19. oktoober 2016, inglise keel, 1DIT, 1DIT

[rb4997d09-5] 5,0 ^5,1 UniChem

[r1a0a8581-6] 6,0 ^6,1 ^6,2 ^6,3 ^6,4 ^6,5 Global Substance Registration System, 19. november 2016, inglise keel, valproic acid, 614OI1Z5WI

[rea04c156-7] N0000020512, 26. veebruar 2018, NDF-RT

[r972aa6d7-8] Freebase Data Dumps, 28. oktoober 2013

[r36765e36-9] California Proposition 65 list of chemicals, 7. jaanuar 2020, https://oehha.ca.gov/chemicals/valproate

[r60f2ee36-10] ChEBI, 19. oktoober 2016, inglise keel, valproic acid, 39867

[r46680b66-11] 11,0 ^11,1 Nuovo soggettario, https://thes.bncf.firenze.sbn.it/termine.php?id=52464, 17. juuni 2021

[r435ed35a-12] 12,0 ^12,1 ^12,2 ^12,3 ^12,4 PubChem, 19. november 2016, inglise keel, 3121, VALPROIC ACID

[r694ee78d-13] 13,0 ^13,1 ^13,2 ^13,3 ^13,4 ^13,5 ^13,6 NIJJYAXOARWZEE-UHFFFAOYSA-N, InChIKey

[raac12ed1-14] Quora

[r4d77d06c-15] YSO-Wikidata mapping project, 9. veebruar 2022

[rc25f63fe-16] 16,0 ^16,1 ChEMBL, 19. jaanuar 2016, inglise keel, Valproic Acid, CHEMBL109

[rfcd831de-17] 17,0 ^17,1 OpenAlex, 26. jaanuar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format

[rdb8780da-18] ChEBI release 2020-09-01

[rf7f9d678-19] CAS Common Chemistry, 9. aprill 2021, NIJJYAXOARWZEE-UHFFFAOYSA-N, https://commonchemistry.cas.org/detail?cas_rn=99-66-1

[r0505f106-20] International Chemical Identifier, InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

[re9d8986b-21] CosIng database, 28. detsember 2019, 94126, VALPROIC ACID, CAS no.: 99-66-1

[rdba273c6-22] DrugBank, inglise keel, 17. november 2015, 00313, Valproic Acid

[r2758fec3-23] 23,0 ^23,1 inferred from InChIKey

[r76075370-24] Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

[r9f11368a-25] ChemSpider, 19. november 2016, inglise keel, 3009, Valproic acid

[rbd47ffca-26] Firenze Keskrahvusraamatukogu

[r26943db7-27] National Library of Israel

[rab4c160e-28] ttps://mednet-communities.net/inn/db/ViewINN.aspx?i=3300

[r978f500f-29] Hazardous Substances Data Bank, 10. mai 2021, 28. oktoober 2019, VALPROIC ACID, 3582

[re0ecf9f9-30] ttps://www.aljazeera.com/economy/2020/8/3/frances-sanofi-charged-with-manslaughter-in-birth-defects-case

[r06c7187b-31] PubChem, 19. oktoober 2016, inglise keel, 3121, VALPROIC ACID

[r42ea14d8-32] Recommended INN: List 13, 1973

[r48741d5f-33] Alkaloid-Bearing Plants and Their Contained Alkaloids. 1957-1968

[r19bf49a3-34] 34,0 ^34,1 ^34,2 ^34,3 N0000147028, 13. detsember 2016, NDF-RT, inglise keel

[r273420b3-35] IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7009, inglise keel

[rbff76a3c-36] Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL109

[r43ffe24a-37] FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links., https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

[r6a5ff9b1-38] 38,0 ^38,1 ^38,2 ^38,3 Medical Subject Headings, 15. märts 2018, D014635

[rc6490174-39] California Proposition 65 list of chemicals, 19. märts 2020, https://oehha.ca.gov/chemicals/valproate

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