Vikipeedia

Prostaglandin-endoperoxide synthase 2

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human enzyme involved in inflammation

Välised allikad

Freebase
/m/02x2zj9[1]
Microsoft Academic ID
2777350520
RefSeq protein ID
NP_000954[2]
Encyclopædia Britannica Online ID
science/cyclooxygenase-2

teema nimetus kujul: cyclooxygenase-2

PDB structure ID
5F1A[3]
5F19[3]
5IKQ[3]
5IKT[3]
5IKV[3]
5IKR[3]
NL CR AUT ID
ph430281

teema nimetus kujul: cyklooxygenáza 2

Ensembl protein ID
ENSP00000356438[4]
ENSP00000454130[5]
UniProt protein ID
P35354[6]

üksikjuht nähtusest

valk[6]

osa objektist

Prostaglandin G/H synthase 2[7]
Haem peroxidase domain superfamily, animal type[7]
Haem peroxidase superfamily[7]
EGF-like domain, protein family[8]

found in taxon

Homo sapiens[6]

encoded by

PTGS2[6]

molecular function

arachidonate 15-lipoxygenase activity[9]

määramismeetod: TAS

metal ion binding[10]

määramismeetod: IEA

heme binding[11][12][13]

määramismeetod: ISS, IEA

enzyme binding[14]

määramismeetod: IPI

oxidoreductase activity[10]

määramismeetod: IEA

protein homodimerization activity[13]

määramismeetod: IEA

dioxygenase activity[10]

määramismeetod: IEA

ravimi seotus vereplasma valkudega[15]

määramismeetod: IPI

peroxidase activity[9][16][17][18]

määramismeetod: IEA, NAS, TAS

prostaglandin-endoperoxide synthase activity[9][17][18][19][20][21]

määramismeetod: IEA, IDA, TAS

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[9][19]

määramismeetod: IEA, TAS

peroxidase activity[22][10][12]

määramismeetod: IEA, NAS

prostaglandin-endoperoxide synthase activity[10][12][13][23][24]

määramismeetod: IDA, IEA

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[13]

määramismeetod: IEA

transferase activity[10]

määramismeetod: IEA

cell component

Tsütoplasma[11][13][25]

määramismeetod: IDA, ISS, IEA

endoplasmic reticulum lumen[26]

määramismeetod: TAS

membrane[10]

määramismeetod: IEA

caveola[13]

määramismeetod: IEA

neuron projection[13][27]

määramismeetod: IDA, IEA

organelle membrane[10]

määramismeetod: IEA

Endoplasmaatiline retiikulum[10][28][29]

määramismeetod: IDA, IEA

intracellular membrane-bounded organelle[10]

määramismeetod: IEA

endoplasmic reticulum membrane[30][10]

määramismeetod: TAS, IEA

protein-containing complex[13]

määramismeetod: IEA

biological process

response to fructose[13]

määramismeetod: IEA

õppimine[13]

määramismeetod: IEA

response to organic substance[13]

määramismeetod: IEA

lipoxygenase pathway[30]

määramismeetod: TAS

cellular response to mechanical stimulus[13]

määramismeetod: IEA

response to manganese ion[13]

määramismeetod: IEA

angiogenesis[13]

määramismeetod: IEA

cellular response to hypoxia[31]

määramismeetod: IEP

embryo implantation[13]

määramismeetod: IEA

negative regulation of cell population proliferation[13]

määramismeetod: IEA

response to cytokine[13]

määramismeetod: IEA

negative regulation of smooth muscle contraction[13]

määramismeetod: IEA

Mälu[13]

määramismeetod: IEA

response to oxidative stress[12]

määramismeetod: IEA

maintenance of blood-brain barrier[13]

määramismeetod: IEA

response to lithium ion[13]

määramismeetod: IEA

response to tumor necrosis factor[13]

määramismeetod: IEA

fatty acid biosynthetic process[10]

määramismeetod: IEA

positive regulation of synaptic transmission, glutamatergic[13]

määramismeetod: IEA

positive regulation of vasoconstriction[13]

määramismeetod: IEA

response to organonitrogen compound[13]

määramismeetod: IEA

inflammatory response[12][13]

määramismeetod: IEA

positive regulation of smooth muscle contraction[13]

määramismeetod: IEA

bone mineralization[13]

määramismeetod: IEA

response to fatty acid[13]

määramismeetod: IEA

response to vitamin D[13]

määramismeetod: IEA

cellular response to UV[13]

määramismeetod: IEA

positive regulation of fever generation[32][13]

määramismeetod: ISS, IEA

cellular response to fluid shear stress[13]

määramismeetod: IEA

positive regulation of synaptic plasticity[13]

määramismeetod: IEA

regulation of blood pressure[11][12][13]

määramismeetod: ISS, IEA

response to lipopolysaccharide[13]

määramismeetod: IEA

positive regulation of platelet-derived growth factor production[32][13]

määramismeetod: ISS, IEA

regulation of inflammatory response[22]

määramismeetod: NAS

brown fat cell differentiation[13]

määramismeetod: IEA

valuaisting[13]

määramismeetod: IEA

response to radiation[13]

määramismeetod: IEA

prostaglandin biosynthetic process[33][11][10][12][13]

määramismeetod: NAS, ISS, IEA

cellular response to ATP[13]

määramismeetod: IEA

Ovulatsioon[13]

määramismeetod: IEA

positive regulation of smooth muscle cell proliferation[13]

määramismeetod: IEA

hair cycle[13]

määramismeetod: IEA

response to estradiol[13]

määramismeetod: IEA

positive regulation of cell death[13]

määramismeetod: IEA

positive regulation of cell migration involved in sprouting angiogenesis[34][13]

määramismeetod: ISS, IEA

response to organic cyclic compound[13]

määramismeetod: IEA

lipid metabolism[10]

määramismeetod: IEA

positive regulation of nitric oxide biosynthetic process[34][13]

määramismeetod: ISS, IEA

response to glucocorticoid[13]

määramismeetod: IEA

cyclooxygenase pathway[30][12][13][24]

määramismeetod: IDA, TAS, IEA

fatty acid metabolic process[10]

määramismeetod: IEA

positive regulation of fibroblast growth factor production[34][13]

määramismeetod: ISS, IEA

Detsidualiseerumine[13]

määramismeetod: IEA

regulation of cell population proliferation[13]

määramismeetod: IEA

positive regulation of cell population proliferation[13]

määramismeetod: IEA

negative regulation of calcium ion transport[13]

määramismeetod: IEA

positive regulation of apoptotic process[13]

määramismeetod: IEA

positive regulation of transforming growth factor beta production[34][13]

määramismeetod: ISS, IEA

positive regulation of vascular endothelial growth factor production[34][13]

määramismeetod: ISS, IEA

positive regulation of brown fat cell differentiation[35][13]

määramismeetod: ISS, IEA

negative regulation of synaptic transmission, dopaminergic[13]

määramismeetod: IEA

cellular oxidant detoxification[36]

määramismeetod: IEA

Vananemine[13]

määramismeetod: IEA

NAD biosynthesis via nicotinamide riboside salvage pathway[30]

määramismeetod: TAS

cellular response to heat[13]

määramismeetod: IEA

positive regulation of prostaglandin biosynthetic process[33][13]

määramismeetod: IEA, NAS

positive regulation of peptidyl-serine phosphorylation[13]

määramismeetod: IEA

negative regulation of apoptotic process[13]

määramismeetod: IEA

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process[13]

määramismeetod: IEA

cellular response to non-ionic osmotic stress[13]

määramismeetod: IEA

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress[13]

määramismeetod: IEA

cellular response to lead ion[13]

määramismeetod: IEA

response to angiotensin[13]

määramismeetod: IEA

prostaglandin metabolic process[10]

määramismeetod: IEA

positive regulation of protein import into nucleus[13]

määramismeetod: IEA

cytokine-mediated signaling pathway[30]

määramismeetod: TAS

long-chain fatty acid biosynthetic process[30]

määramismeetod: TAS

negative regulation of cell cycle[13]

määramismeetod: IEA

regulation of neuroinflammatory response[11][13]

määramismeetod: IEA, ISS

physically interacts with

Aspiriin[37]

kasutus: Ensüümiinhibiitor

benzquinamide[38]

kasutus: Ensüümiinhibiitor

Karprofeen[39]

kasutus: Ensüümiinhibiitor

celecoxib[40]

kasutus: Ensüümiinhibiitor

Diclofenac[41]

kasutus: Ensüümiinhibiitor

(RS)-etodolac[42]

kasutus: Ensüümiinhibiitor

etorikoksiib[43]

kasutus: Ensüümiinhibiitor

(+-)-flurbiprofen[44]

kasutus: Ensüümiinhibiitor

ibuprofeen[45]

kasutus: Ensüümiinhibiitor

(RS)-ketoprofen[46]

kasutus: Ensüümiinhibiitor

ketorolac[47]

kasutus: Ensüümiinhibiitor

lumiracoxib[48]

kasutus: Ensüümiinhibiitor

meclofenamic acid[49]

kasutus: Ensüümiinhibiitor

mefenamic acid[50]

kasutus: Ensüümiinhibiitor

meloksikaam[51]

kasutus: Ensüümiinhibiitor

Naprokseen[52]

kasutus: Ensüümiinhibiitor

nimesulide[53]

kasutus: Ensüümiinhibiitor

NS-398[54]

kasutus: Ensüümiinhibiitor

oxaprozin[55]

kasutus: Ensüümiinhibiitor

paratsetamool[56]

kasutus: Ensüümiinhibiitor

phenylbutazone[57]

kasutus: Ensüümiinhibiitor

piroxicam[58]

kasutus: Ensüümiinhibiitor

resveratrol[59]

kasutus: Ensüümiinhibiitor

Rofekoksiib[60]

kasutus: Ensüümiinhibiitor

suprofen[61]

kasutus: Ensüümiinhibiitor

valdecoxib[62]

kasutus: Ensüümiinhibiitor

Naprokseen[63]

objektil on roll: Inhibiitor

diclofenac sodium[64]

objektil on roll: Inhibiitor

iguratimod[65]

objektil on roll: Inhibiitor

oxaprozin[66]

objektil on roll: Inhibiitor

apricoxib[67]

objektil on roll: Inhibiitor

Aspiriin[68]

objektil on roll: Inhibiitor

ibuprofeen[69]

objektil on roll: Inhibiitor

polmacoxib[70]

objektil on roll: Inhibiitor

ketorolac[71]

objektil on roll: Inhibiitor

isoxicam[72]

objektil on roll: Inhibiitor

Diclofenac[73]

objektil on roll: Inhibiitor

(RS)-etodolac[74]

objektil on roll: Inhibiitor

bromfenac[75]

objektil on roll: Inhibiitor

(RS)-fenoprofen[76]

objektil on roll: Inhibiitor

diflunisal[77]

objektil on roll: Inhibiitor

esflurbiprofen[78]

objektil on roll: Inhibiitor

diclofenac potassium[79]

objektil on roll: Inhibiitor

(RS)-fenoprofen calcium dihydrate[80]

objektil on roll: Inhibiitor

ketorolac tromethamine[81]

objektil on roll: Inhibiitor

naproxen sodium[82]

objektil on roll: Inhibiitor

tolmetin sodium[83]

objektil on roll: Inhibiitor

EC enzyme number

1.14.99.1

täpne vaste

http://purl.uniprot.org/uniprot/P35354[84]

koosseisu osa

EGF-like domain[7]

Commonsi kategooria

Cyclooxygenase 2

Viited

  1. ↑ Freebase Data Dumps, 28. oktoober 2013
  2. ↑ NCBI Gene, 30. mai 2020, 5743
  3. ↑ 3,0 3,1 3,2 3,3 3,4 3,5 P35354, 9. august 2016, UniProt, inglise keel
  4. ↑ Ensembl Release 99, ENSP00000356438
  5. ↑ Ensembl Release 99, ENSP00000454130
  6. ↑ 6,0 6,1 6,2 6,3 UniProt, 13. november 2019, P35354
  7. ↑ 7,0 7,1 7,2 7,3 InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P35354
  8. ↑ inferred from protein domain or family
  9. ↑ 9,0 9,1 9,2 9,3 TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, 7. november 2018, Reactome, GOA
  10. ↑ 10,00 10,01 10,02 10,03 10,04 10,05 10,06 10,07 10,08 10,09 10,10 10,11 10,12 10,13 10,14 10,15 IEA, 9. mai 2019, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  11. ↑ 11,0 11,1 11,2 11,3 11,4 ISS, 9. mai 2019, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  12. ↑ 12,0 12,1 12,2 12,3 12,4 12,5 12,6 12,7 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, InterPro, GOA
  13. ↑ 13,00 13,01 13,02 13,03 13,04 13,05 13,06 13,07 13,08 13,09 13,10 13,11 13,12 13,13 13,14 13,15 13,16 13,17 13,18 13,19 13,20 13,21 13,22 13,23 13,24 13,25 13,26 13,27 13,28 13,29 13,30 13,31 13,32 13,33 13,34 13,35 13,36 13,37 13,38 13,39 13,40 13,41 13,42 13,43 13,44 13,45 13,46 13,47 13,48 13,49 13,50 13,51 13,52 13,53 13,54 13,55 13,56 13,57 13,58 13,59 13,60 13,61 13,62 13,63 13,64 13,65 13,66 13,67 13,68 13,69 13,70 13,71 13,72 13,73 13,74 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Ensembl genome database project, GOA
  14. ↑ IPI, 9. mai 2019, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  15. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
  16. ↑ NAS, 7. november 2018, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
  17. ↑ 17,0 17,1 IEA, 7. november 2018, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
  18. ↑ 18,0 18,1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, 7. november 2018, InterPro, GOA
  19. ↑ 19,0 19,1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, 7. november 2018, Ensembl genome database project, GOA
  20. ↑ IDA, 7. november 2018, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
  21. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, 7. november 2018, British Heart Foundation, Human cyclooxygenase-2 cDNA, GOA
  22. ↑ 22,0 22,1 NAS, 9. mai 2019, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  23. ↑ IDA, 9. mai 2019, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  24. ↑ 24,0 24,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, British Heart Foundation, Human cyclooxygenase-2 cDNA, GOA
  25. ↑ IDA, 9. mai 2019, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  26. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
  27. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Mouse Genome Informatics, Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina, GOA
  28. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
  29. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Human Protein Atlas, GOA
  30. ↑ 30,0 30,1 30,2 30,3 30,4 30,5 TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Reactome, GOA
  31. ↑ IEP, 9. mai 2019, P35354, Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  32. ↑ 32,0 32,1 ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, British Heart Foundation, GOA
  33. ↑ 33,0 33,1 NAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, British Heart Foundation, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA
  34. ↑ 34,0 34,1 34,2 34,3 34,4 ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, British Heart Foundation, Cyclooxygenase regulates angiogenesis induced by colon cancer cells, GOA
  35. ↑ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, British Heart Foundation, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA
  36. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Gene Ontology Consortium, GOA
  37. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 4139, inglise keel
  38. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7124, inglise keel
  39. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7141, inglise keel
  40. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2892, inglise keel
  41. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2714, inglise keel
  42. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7185, inglise keel
  43. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2896, inglise keel
  44. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 4194, inglise keel
  45. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2713, inglise keel
  46. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 4795, inglise keel
  47. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 6661, inglise keel
  48. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2897, inglise keel
  49. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7219, inglise keel
  50. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2593, inglise keel
  51. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7220, inglise keel
  52. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 5230, inglise keel
  53. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7401, inglise keel
  54. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 8976, inglise keel
  55. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7252, inglise keel
  56. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 5239, inglise keel
  57. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7270, inglise keel
  58. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7273, inglise keel
  59. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 8741, inglise keel
  60. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2893, inglise keel
  61. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7298, inglise keel
  62. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2894, inglise keel
  63. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL154
  64. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1034
  65. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL2107455
  66. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1071
  67. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1835207
  68. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL25
  69. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL521
  70. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL166863
  71. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL469
  72. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL53292
  73. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL139
  74. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL622
  75. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1077
  76. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1297
  77. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL898
  78. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL435298
  79. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1200804
  80. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL2103736
  81. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1201124
  82. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1200806
  83. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1200613
  84. ↑ Identifiers.org
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