Vikipeedia

Phosphodiesterase 5A

Loo artikkel

See on automaatne vaade, mis põhineb projekti Vikiandmed andmetel.
Artiklit veel pole, kuid saad aidata seda luua.

mammalian protein found in Homo sapiens

Välised allikad

Freebase
/m/065dqy[1]
Microsoft Academic ID
74534348
RefSeq protein ID
NP_001074[2]
NP_236914[2]
NP_246273[2]
XP_016864280[2]
Ensembl protein ID
ENSP00000347046[3]
ENSP00000264805[4]
ENSP00000377957[5]
ENSP00000416309[6]
ENSP00000425810[7]
PDB structure ID
4OEX[8]
1RKP[8]
1T9R[8]
1T9S[8]
1TBF[8]
1UDT[8]
1UDU[8]
1UHO[8]
1XOZ[8]
1XP0[8]
2CHM[8]
2H40[8]
2H42[8]
2H44[8]
2XSS[8]
3B2R[8]
3BJC[8]
3HC8[8]
3HDZ[8]
3JWQ[8]
3JWR[8]
3LFV[8]
3MF0[8]
3SHY[8]
3SHZ[8]
3SIE[8]
3TGE[8]
3TGG[8]
4G2W[8]
4G2Y[8]
4I9Z[8]
4IA0[8]
4MD6[8]
4OEW[8]
OpenAlex ID
C74534348[9]
UniProt protein ID
O76074[10]

üksikjuht nähtusest

valk[10]

osa objektist

3'5'-cyclic nucleotide phosphodiesterase[11]
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily[11]
GAF-like domain superfamily[11]
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family[12]
HD/PDEase domain, protein family[12]
GAF domain, protein family[12]
3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family[12]

found in taxon

Homo sapiens[10]

encoded by

PDE5A[10]

molecular function

nucleotide binding[13]

määramismeetod: IEA

3',5'-cyclic-nucleotide phosphodiesterase activity[14][15][16]

määramismeetod: NAS, IEA

cGMP binding[17][18][19]

määramismeetod: IEA, TAS

metal ion binding[13]

määramismeetod: IEA

cyclic-nucleotide phosphodiesterase activity[16]

määramismeetod: IEA

catalytic activity[13]

määramismeetod: IEA

phosphoric diester hydrolase activity[15]

määramismeetod: IEA

hydrolase activity[13]

määramismeetod: IEA

3',5'-cyclic-GMP phosphodiesterase activity[20][21]

määramismeetod: IEA, TAS

ravimi seotus vereplasma valkudega[22]

määramismeetod: IPI

3',5'-cyclic-GMP phosphodiesterase activity[23][18][24]

määramismeetod: IDA, IEA, TAS

cGMP binding[25][13][16][26]

määramismeetod: IBA, IEA, TAS

3',5'-cyclic-GMP phosphodiesterase activity[20][21][27][28]

määramismeetod: IBA, IDA, IEA, TAS

3',5'-cyclic-GMP phosphodiesterase activity[13][29][26]

määramismeetod: IBA, IDA, IEA

cell component

tsütosool[30]

määramismeetod: TAS

cellular component[31]

määramismeetod: ND

biological process

positive regulation of MAP kinase activity[16]

määramismeetod: IEA

cGMP metabolic process[16]

määramismeetod: IEA

positive regulation of cardiac muscle hypertrophy[16]

määramismeetod: IEA

cGMP catabolic process[21][32][27]

määramismeetod: IDA, IEA

negative regulation of T cell proliferation[16]

määramismeetod: IEA

positive regulation of oocyte development[16]

määramismeetod: IEA

Metabolism[13]

määramismeetod: IEA

relaxation of cardiac muscle[16]

määramismeetod: IEA

Signaaliülekanne[15]

määramismeetod: IEA

negative regulation of cardiac muscle contraction[16]

määramismeetod: IEA

regulation of nitric oxide mediated signal transduction[16]

määramismeetod: IEA

cGMP catabolic process[13][16]

määramismeetod: IEA

physically interacts with

ibudilast[33]

kasutus: Ensüümiinhibiitor

milrinone[34]

kasutus: Ensüümiinhibiitor

SCH-51866[35]

kasutus: Ensüümiinhibiitor

Sildenafiil[36]

kasutus: Ensüümiinhibiitor

tadalafil[37]

kasutus: Ensüümiinhibiitor

vardenafil[38]

kasutus: Ensüümiinhibiitor

zaprinast[39]

kasutus: Ensüümiinhibiitor

Sildenafiil[40]

objektil on roll: Inhibiitor

ibudilast[41]

objektil on roll: Inhibiitor

gisadenafil[42]

objektil on roll: Inhibiitor

EC enzyme number

3.1.4.35

Gene Atlas image

täpne vaste

http://purl.uniprot.org/uniprot/O76074[43]

koosseisu osa

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain[11]
HD/PDEase domain[11]
GAF domain[11]
3'5'-cyclic nucleotide phosphodiesterase, conserved site[11]

Commonsi kategooria

Phosphodiesterase 5

Viited

  1. ↑ Freebase Data Dumps, 28. oktoober 2013
  2. ↑ 2,0 2,1 2,2 2,3 NCBI Gene, 30. mai 2020, 8654
  3. ↑ Ensembl Release 99, ENSP00000347046
  4. ↑ Ensembl Release 99, ENSP00000264805
  5. ↑ Ensembl Release 99, ENSP00000377957
  6. ↑ Ensembl Release 99, ENSP00000416309
  7. ↑ Ensembl Release 99, ENSP00000425810
  8. ↑ 8,00 8,01 8,02 8,03 8,04 8,05 8,06 8,07 8,08 8,09 8,10 8,11 8,12 8,13 8,14 8,15 8,16 8,17 8,18 8,19 8,20 8,21 8,22 8,23 8,24 8,25 8,26 8,27 8,28 8,29 8,30 8,31 8,32 8,33 O76074, 4. august 2016, UniProt, inglise keel
  9. ↑ OpenAlex, 26. jaanuar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  10. ↑ 10,0 10,1 10,2 10,3 UniProt, 13. november 2019, O76074
  11. ↑ 11,0 11,1 11,2 11,3 11,4 11,5 11,6 InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/O76074
  12. ↑ 12,0 12,1 12,2 12,3 inferred from protein domain or family
  13. ↑ 13,0 13,1 13,2 13,3 13,4 13,5 13,6 13,7 IEA, 8. aprill 2019, O76074, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074, UniProt
  14. ↑ NAS, 8. aprill 2019, O76074, Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074, UniProt
  15. ↑ 15,0 15,1 15,2 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074, 8. aprill 2019, InterPro, GOA
  16. ↑ 16,00 16,01 16,02 16,03 16,04 16,05 16,06 16,07 16,08 16,09 16,10 16,11 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074, 8. aprill 2019, Ensembl genome database project, GOA
  17. ↑ TAS, 21. juuni 2018, O76074, Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074, UniProt
  18. ↑ 18,0 18,1 IEA, 21. juuni 2018, O76074, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074, UniProt
  19. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074, 21. juuni 2018, Ensembl genome database project, GOA
  20. ↑ 20,0 20,1 TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074, 1. jaanuar 2018, Reactome, GOA
  21. ↑ 21,0 21,1 21,2 IEA, 1. jaanuar 2018, O76074, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074, UniProt
  22. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074, 8. aprill 2019, IntAct protein interaction database, Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions, GOA
  23. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074, 21. juuni 2018, Reactome, GOA
  24. ↑ IDA, 21. juuni 2018, O76074, Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074, UniProt
  25. ↑ TAS, 8. aprill 2019, O76074, Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074, UniProt
  26. ↑ 26,0 26,1 IBA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074, 8. aprill 2019, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
  27. ↑ 27,0 27,1 IDA, 1. jaanuar 2018, O76074, Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074, UniProt
  28. ↑ IBA, http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074, 1. jaanuar 2018, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
  29. ↑ IDA, 8. aprill 2019, O76074, Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074, UniProt
  30. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074, 8. aprill 2019, Reactome, GOA
  31. ↑ ND, 8. aprill 2019, O76074, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074, UniProt
  32. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074, 1. jaanuar 2018, Ensembl genome database project, GOA
  33. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7399, inglise keel
  34. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 5225, inglise keel
  35. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 5270, inglise keel
  36. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 4743, inglise keel
  37. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7299, inglise keel
  38. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7320, inglise keel
  39. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2919, inglise keel
  40. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL192
  41. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL19449
  42. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1928262
  43. ↑ Identifiers.org
Pärit leheküljelt "https://et.wikipedia.org/wiki/Eri:AboutTopic/Q410798"