Kasutaja:Jaan/liivakast

Mait Metspalu 2011. aastal Tartus TÜ MRI hoones. Foto: Lauri Kulpsoo.

Mait Metspalu (sündinud 24. augustil 1975) on eesti evolutsioonigeneetik.

2005. aastal kaitses ta Tartu Ülikoolis doktorikraadi teemal "Through the course of prehistory in India: tracing the mtDNA trail".

Alates 2005. aastast on Mait Metspalu Eesti Biokeskuse teadur. Teadusprojekti "Eesti Genoomikakeskus" juht, mille eesmärk on Eesti Geenivaramu genoomiandmestiku ja tarkvaralahenduste täiendamine ning referentsgenoomiandmestiku loomine teiste populatsioonide baasil, pakkudes vajaliku konteksti Eesti Geenivaramu genoomiandmestikule.

Isiklikku

Mait Metspalu isa on Eesti Geenivaramu direktor Andres Metspalu.

Valitud bibliograafia

• Pagani,Luca; Lawson, Daniel John; Jagoda, Evelyn; ... Metspalu, Mait (2016). Genomic analyses inform on migration events during the peopling of Eurasia. Nature
• Yunusbayev, B.; Metspalu, M.; Metspalu, E.; ... Villems, R. (2015). The Genetic Legacy of the Expansion of Turkic-Speaking Nomads Across Eurasia. Plos Genetics, 11 (4), e1005068, journal.pgen.1005068.
• Cardona, A; Pagani, L; Antao, T; ... Metspalu, M; ... Kivisild, T. (2014). Genome-wide analysis of cold adaptation in indigenous siberian populations. PLoS ONE, 9 (5)
• Raghavan, M.; Skoglund, P.; Graf, K.E.; Metspalu, M.; ... Willerslev, E. (2014). Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature, 505 (7481), 87−91
• Christofaro, J.; Pennarun, E.; Mazires, S.; ... Metspalu, M.; ... Chiaroni, J. (2013). Afghan Kindu Kush where Eurasian sub-continent gene flows converge. PLoS ONE, 8 (10)
• Fedorova, Sardana; Reidla, Maere; Metspalu, Ene; Metspalu, Mait; ... Villems, Richard (2013). Autosomal and uniparental portraits of the native populations of Sakha (Yakutia): implications for the peopling of Northeast Eurasia. BMC Evolutionary Biology, 127.
• Migliano, A.; Romero, I.; Metspalu, M.; ... Kivisild, T. (2013). Evolution of the pygmy phenotype: evidence of positive selection from genome-wide scans in African, Asian and Melanesian pygmies. Human Biology, 85, 251−284.
• Behar, DM.; Metspalu, M.; Baran, Y.; ... Rosenberg, N. (2013). No Evidence from Genome-Wide Data of a Khazar Origin for the Ashkenazi Jews. Human Biology, 85 (6), 859−900.
• Rootsi, S.; Behar, D.; Järve, M.; ... Metspalu, M.; ... Underhill, P. (2013). Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites. Nature Communications, 4, Article 2928
• Basu Mallick, C; Iliescu, FM; Möls, M, Hill; S, Tamang, R; Chaubey, G; Goto, R; Ho, SY; Gallego Romero, I; Crivellaro, F; Hudjashov, G; Rai, N; Metspalu, M; Mascie-Taylor, CG; Pitchappan, R; Singh, L; Mirazon-Lahr, M; Thangaraj, K; Villems, R; Kivisild, T. (2013). The Light Skin Allele of SLC24A5 in South Asians and Europeans Shares Identity by Descent. Plos Genetics, 9 (11), e1003912, journal.pgen.1003912.
• Behar, D.M.; van Oven, M.; Rosset, S.; Metspalu, M.; ... Villems, R. (2012). A "Copernican" Reassessment of the Human Mitochondrial DNA Tree from its Root. American Journal of Human Genetics, 90 (4), 675−84.
• Pennarun, E.; Kivisild, T.; Metspalu, E.; Metspalu, M.; Reisberg, T.; Behar, D.M.; Jones, S.; Villems, R. (2012). Divorcing the Late Upper Palaeolitic Demographic Histories of mtDNA Haplogroupa M1 and U6 in Africa. BMC Evolutionary Biology, 12, 234.

Gallego Romero, I; Basu Mallick, C; Liebert, A; Crivellaro, F; Chaubey, G; Itan, Y; Metspalu, M; Eaaswarkhanth, M; Pitchappan, R; Villems, R; Reich, D; Singh, L; Thangaraj, K; Thomas, MG; Swallow, DM; Mirazon Lahr, M; Kivisild, T. (2012). Herders of Indian and European Cattle Share Their Predominant Allele for Lactase Persistence. Molecular Biology and Evolution, 29(1), 249−60. Yunusbayev, B.; Metspalu, M.; Järve, M.; Kutujev, I.; Rootsi, S.; Metspalu, E.; Behar, D. M.; Varendi, K.; Sahakyan, H.; Khusainova, R.; Yepiskoposyan, L.; Khusnutdinova, E. K.; Underhill, P. A.; Kivisild, T.; Villems, R. (2012). The Caucasus as an asymmetric semipermeable barrier to ancient human migrations. Molecular Biology and Evolution, 29(1), 359−65. Rasmussen, M.; Guo, X.; Wang, Y.; Lohmueller, K. E.; Rasmussen, S.; Albrechtsen, A.; Skotte, L.; Lindgreen, S.; Metspalu, M.; Jombart, T.; Kivisild, T.; Zhai, W.; Erikson, A.; Manica, A.; Orlando, L.; De La Vega, F.; Tridico, S.; Metspalu, E.; Nielsen, K.; Avila-Arcos, M.C. ... Willerslev, E. (2011). An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia. Science, 334(6052), 94−8. Chaubey, Gyaneshwer; Metspalu, Mait; Choi, Ying; Mägi, Reedik; Gallego Romero, Irene; Soares, Pedro; van Oven, Mannis; Behar, Doron M; Rootsi, Siiri; Hudjashov, Georgi; Basu Mallick, Chandana; Karmin, Monika; Nelis, Mari; Parik, Jüri; Goverdhana Reddy, Alla; Metspalu, Ene; vanDriem, George; Xue, Yali; Tyler-Smith, Chris; Thangaraj, Kumarasamy ... Kivisild, Toomas. (2011). Population Genetic Structure in Indian Austroasiatic speakers: The Role of Landscape Barriers and Sex-specific Admixture. Molecular Biology and Evolution, 28(2), 1013−24. Metspalu, M.; Romero, IG.; Yunusbayev, B.; Chaubey, G.; Mallick, CB.; Hudjashov, G.; Nelis, M.; Mägi, R.; Metspalu, E.; Remm, M.; Pitchappan, R.; Singh, L.; Thangaraj, K.; Villems, R.; Kivisild, T. (2011). Shared and unique components of human population structure and genome-wide signals of positive selection in South Asia. American Journal of Human Genetics, 89 (6), 731−44, j.ajhg.2011.11.010. Rasmussen, M.; Li, Y.; Lindgreen, S.; Pedersen, J.S.; Albrechtsen, A.; Moltke, I.; Metspalu, M.; Metspalu, E.; Kivisild, T.; Gupta, R.; Bertalan, M.; Nielsen, K.; Gilbert, M.T.; Wang, Y.; Raghavan, M.; Campos, P.F.; Kamp, H.M.; Wilson, A.S.; Gledhill, A.; Tridico, S. ... Willerslev, E. (2010). Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature, 757−762, nature08835. Underhill, P.A.; Myres, N.M.; Rootsi, S.; Metspalu, M.; Zhivotovsky, L.A.; King, R.J.; Lin, A.A.; Chow, C.E.; Semino, O.; Battaglia, V.; Kutuev, I.; Järve, M.; Chaubey, G.; Ayub, Q.; Mohyuddin, A.; Mehdi, S.Q.; Sengupta, S.; Rogaev, E.I.; Khusnutdinova, E.K.; Pshenichnov, A. ... Kivisild, T. (2010). Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a. European Journal of Human Genetics, 18 (4), 479−484. Behar, Doron M; Yunusbayev, Bayazit; Metspalu, Mait; Metspalu, Ene; Rosset, Saharon; Parik, Jüri; Rootsi, Siiri; Chaubey, Gyaneshwer; Kutuev, Ildus; Yudkovsky, Guennady; Khusnutdinova, K. Elza; Balanovsky, Oleg; Semino, Ornella; Pereira, Luisa; Comas, David; Gurwitz, David; Bonne-Tamir, Batsheva; Parfitt, Tudor; Hammer, Michael F.; Skorecki, Karl ... Villems, Richard. (2010). The genome-wide structure of the Jewish people. Nature, 238−42, nature09103. Petraglia, M; Clarkson, C; Boivin, N; Haslam, M; Korisettar, R; Chaubey, G; Ditchfield, P; Fuller, D; James, H; Jones, S; Kivisild, T; Koshy, J; LahrM, M; Metspalu, M; Roberts, R; ArnoldL, L. (2009). Population increase and environmental deterioration correspond with microlithic innovations in South Asia ca. 35,000 years ago. PNAS, 106 (30), 12261−12266, pnas.0810842106. Barik, SS; Sahani, R; Prasad, BV; Endicott, P; Metspalu, M; Sarkar, BN; Bhattacharya, S; Annapoorna, PC; Sreenath, J; Sun, D; Sanchez, JJ; Ho, SY; Chandrasekar, A; Rao, VR. (2008). Detailed mtDNA genotypes permit a reassessment of the settlement and population structure of the Andaman Islands. American Journal of Physical Anthropology, 19−27. Chaubey, G.; Metspalu, M.; Karmin, M.; Thangaraj, K.; Rootsi, S.; Parik, J.; Solnik, A.; Rani, D.S.; Singh, V.K.; Naidu, B.P.; Reddy, A.G.; Metspalu, E.; Singh, L.; Kivisild, T.; Villems, R. (2008). Language Shift by Indigenous Population: A Model Genetic Study in South Asia. International Journal of Human Genetics, 8, 41−50. Thangaraj, K; Chaubey, G; Kivisild, T; Selvi Rani, D; Singh, VK; Ismail, T; Carvalho-Silva, D; Metspalu, M; Bhaskar, LV; Reddy, AG; Chandra, S; Pande, V; Prathap Naidu, B; Adarsh, N; Verma, A; Jyothi, IA; Mallick, CB; Shrivastava, N; Devasena, R; Kumari, B ... Singh, L. (2008). Maternal Footprints of Southeast Asians in North India. Human Heredity, 66 (1), 1−9. Gilbert, M.T.; Kivisild, T.; Grønnow, B.; Andersen, P.K.; Metspalu, E.; Reidla, M.; Tamm, E.; Axelsson, E.; Götherström, A.; Campos, P.F.; Rasmussen, M.; Metspalu, M.; Higham, T.F.; Schwenninger, J.L.; Nathan, R.; De, Hoog, C.J.; Koch, A.; Møller, L.N.; Andreasen, C.; Meldgaard, M. ... Willerslev, E. (2008). Paleo-Eskimo mtDNA Genome Reveals Matrilineal Discontinuity in Greenland. Science, 1787−1789. Chaubey, G.; Karmin, M.; Metspalu, E.; Metspalu, M.; Selvi-Rani, D.; Singh, V.K.; Parik, J.; Solnik, A.; Naidu, B.P.; Kumar, A.; Adarsh, N.; Mallick, C.B., Trivedi, B.; Prakash, S.; Reddy, R.; Shukla, P.; Bhagat, S.; Verma, S.; Vasnik, S.; Khan, I.; Barwa, A. ... Villems, R. (2008). Phylogeography of mtDNA haplogroup R7 in the Indian peninsula. BMC Evolutionary Biology, 8 (227), x−x, 1471-2148-8-227. Tamm, E.; , Kivisild, T.; Reidla, M.; Metspalu, M.; Smith, D.G.; Mulligan, C.J.; Bravi, C.M.; Rickards, O.; Martinez-Labarga, C.; Khusnutdinova, E.K.; Fedorova, S.A.; Golubenko, M.V.; Stepanov, V.A.; Gubina, M.A.; Zhadanov, S.I.; Ossipova, L.P.; Damba, L.; Voevoda, M.I.; Dipierri, J.E.; Villems, R. ... Malhi, R.S. (2007). Beringian standstill and spread of Native American founders. PLoS ONE, 9, e829. Chaubey, G.; Metspalu, M.; Kivisild, T.; Villems, R. (2007). Peopling of South Asia: investigating the caste-tribe continuum in India. Bioessays, 29 (1), 91−100. Endicott, P.; Metspalu, M.; Kivisild, T. (2007). Genetic evidence on modern human dispersals in South Asia: Y chromosome and mitochondrial DNA perspectives. In: Petraglia M.-D.; Allchin,B. (Ed.). The Evolution and History of Human Populations in South Asia (229−244). Springer. (Vertebrate Paleobiology and Paleoanthropology). Sahoo, S.; Singh, A.; Himabindu, G.; Banerjee, J.; Sitalaximi, T.; Gaikwad, S.; Trivedi, R.; Endicott, P.; Kivisild, T.; Metspalu, M.; Villems, R.; Kashyap, VK. (2006). A prehistory of Indian Y chromosomes: Evaluating demic diffusion scenarios. Proceedings of the National Academy of Sciences of the United States of America, 103 (4), 843−848. Endicott, P.; Metspalu, M.; Stringer, C.; Macaulay, V.; Cooper, A.; Sanchez, J. (2006). Multiplexed SNP Typing of Ancient DNA Clarifies the Origin of Andaman mtDNA Haplogroups amongst South Asian Tribal Populations. PLoS ONE, 1 (1), e81, journal.pone.0000081. Metspalu, Mait; Kivisild, T; Bandelt, H-J; Richards, M; Villems, R (2006). The pioneer settlement of modern humans in Asia. In: Bandelt, H-J; Macaulay, V; Richards, M. (Ed.). Human mitochondrial DNA and the evolution of Homo sapiens (179−197). Springer Heidelberg. Metspalu, M.; Kivisild, T.; Metspalu, E.; Parik, J.; Hudjashov, G.; Kaldma, K.; Serk, P.; Karmin, M.; Behar, DM.; Gilbert, MTP.; Endicott, P.; Mastana, S.; Papiha, SS.; Skorecki, K.; Torroni, A.; Villems, R. (2004). Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans. BMC Genetics, 5, 26.. Kivisild, T.; Rootsi, S.; Metspalu, M.; Mastana, S.; Kaldma, K.; Parik, J.; Metspalu, E.; Adojaan, M.; Tolk, HV.; Stepanov, V.; Golge, M.; Usanga, E.; Papiha, SS.; Cinnioglu, C.; King, R.; Cavalli-Sforza, L.; Underhill, PA.; Villems, R. (2003). The genetic heritage of the earliest settlers persists both in Indian tribal and caste populations. American Journal of Human Genetics, 72 (2), 313−332. Kivisild, T.; Bamshad, MJ.; Kaldma, K.; Metspalu, M.; Metspalu, E.; Reidla, M.; Laos, S.; Parik, J.; Watkins, WS.; Dixon, ME.; Papiha, SS.; Mastana, SS.; Mir, MR.; Ferak, V.; Villems, R. (1999). Deep common ancestry of Indian and western-Eurasian mitochondrial DNA lineages. Current Biology, 9 (22), 1331−1334.

Välislingid

• "Geeniuurija Mait Metspalu: peagi teame enam ka eestlaste juurtest" Eesti Päevaleht, 16. juuni 2010
• "Mait Metspalu. Inimese geneetilisest varieeruvusest" Ööülikool, 2011
• Evaluating the mitochondrial timescale of human evolution